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Reference: Kusminski, Christine M., et al

Monocyte Chemoattractant Protein-4 (MCP-4)/CCL13 is Highly Expressed in Cartilage From Patients With Rheumatoid Arthritis

The widely repeated claim that it is ~ten-million-fold more potent than BDNF is a relative in-vitro spine-counting ratio, not a human effect, and key mechanism papers from the originating lab were retracted in 2025